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I am running a Focusrite USB Audio interface.
First, what is your chosen input and output APO? (ASIO, Direct Sound, WASAPI, MME, etc?) If one is giving you trouble, try another. Also the lower your Diversity Delay buffer, the more likely you will get audio glitches.
I would make sure to use the ASIO driver and selection in Stereo Tool's HD output since this interface is supposed to come with its own ASIO driver. I get a stable signal and buffer bar with a relatively low delay buffer (less than 80ms) with my ASIO devices.
Also, the underlying I/O code is currently in the process of being rewritten. So, keep an eye out for that to come to beta sooner or later.