I'm using the latest beta (7.41.035); it's been like this since I put the new PC in place (with 7.41.025, I think).
I have the latency for Stereo Tool set at 4096 samples, the quality at 50%, and display refresh speed at 50%. On StationPlaylist Studio, I have the buffer size at the maximum (2000 ms).
The soundcard is labeled about as generic as can be: "High Definition Audio Device (Microsoft)."
I've just increased the priority of the sound driver, so we will see if perhaps that will help.
I guess there's no way to go USB-to-USB, eh?
EDIT: EVERYTHING is integrated on the MOBO: video, sound, NIC card. Would putting in PCI cards for some or all of these things maybe make the audio smoother?